M101 is the brightest of a group of at least 9 galaxies, called the M101 Group. The brightest companions are NGC 5474 (type Sc, 10.85 mag vis) to the SSE and NGC 5585 (Sa, 11.49 mag; Glyn Jones and Burnham misprinted this as 5485) to the NE. Other probable group members are NGC 5204 (Ir, 11.26), NGC 5238 (SB(d)m, 13.35p), NGC 5477 (Ir+, 13.8), UGC 8508 (Ir+, 14.5 p), Holmberg IV (UGC 8837, Ir+, 13.1 p), and UGC 9405.

The distance of M101 has been determined by the measurement of Cepheid variables with the Hubble Space Telescope in 1994/95 to be about 24 +/- 2 million light years, by the HST H0 Key Project Team (paper III, 1996). Kenneth Glyn Jones mentions earlier Earth-bound attempts of 1986, when two Cepheids were claimed to have been detected (yielding distance estimates between 20 and 26 million light years). It is also in good agreement with a distance determined from the Planetary Nebula Luminosity function, by Feldmeier, Ciardullo and Jacoby (1996) which is 25.1 +/- 1.6 million light years. According to the recent recalibration of the Cepheid distance scale, the "true" distance of M101 should be closer to a 10 percent higher value (27 million light years).

At the new distance from the HST and Hipparcos, it has a linear diameter of over 170,000 light years and is thus among the biggest disk galaxies, and its total apparent visual brightness of 7.9 mag corresponds to an absolute brightness of -21.6 magnitudes, or a luminosity of about 30 billion (3*10^10) times that of our sun.